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Researchers are seeking more funding, faster approvals and domestic production of new drugs
German doctors are warning that the world risks going back to the era before the discovery of penicillin, Bild reported on Monday. Medics are pointing to a rise in antibiotic-resistant pathogens, the newspaper added.
Penicillin, discovered in the late 1920s, dramatically extended the human lifespan by up to 30 years by countering most bacterial infections. All of that progress is now reportedly in peril.
“We are currently losing the achievements of modern medicine and falling back into the time before the discovery of penicillin,” Mathias Pletz, head of the Paul Ehrlich Society for Infection Therapy, told Bild.
“Antibiotics were the greatest achievement of medicine ever,” said Professor Yvonne Mast, a microbiologist and researcher at the Leibniz Institute in Braunschweig. “The fact that more and more resistance is now emerging and new antibiotics are lacking is a major threat.”
The German outlet quoted a study that estimated up to 39 million deaths around the world by 2050 due to antibiotic-resistant pathogens. Such infections already account for 35,000 deaths in the EU every year.
According to Professor Frank Brunkhorst of the Jena University Hospital, one of the reasons is that doctors overprescribe antibiotics for outpatient procedures. For example, antibiotics are useless against almost all respiratory infections, which are caused by viruses.
“Second, many resistant germs are coming to us due to international travel, which is booming again after [Covid],” Brunkhorst said, pointing to resistant strains “especially in countries like Greece, Portugal, Turkiye, but also in India and other Asian countries.”
He warned Germans returning from vacations that the germs they bring back could be “life-threatening” to their grandparents.
The medical industry has been slow to develop new antibiotics because the research is too long and too expensive, while the profits are too low, according to Professor Mast. Only 12 new medications have been approved since 2017, she said.
Only one in 5,000 substances reaches market maturity, the development period is anywhere from 8-15 years, and R&D costs can range up to $2 billion, according to Mast. She urged more funding for research and faster approvals, noting that China has already overtaken Germany in this field.
“It is a huge task for politicians to bring antibiotic production back to Germany and Europe. Today, not a single drug is manufactured here anymore; everything comes from India or China. And we are dependent on it,” said Professor Brunkhorst.
